Extensive sex differences at the initiation of genetic recombination
نویسندگان
چکیده
منابع مشابه
Sex differences in recombination
One of the stronger empirical generalizations to emerge from the study of genetic systems is that achiasmate meiosis, which has evolved 25-30 times, is always restricted to the heterogametic sex in dioecious species. usually the male. Here we collate data on quantitative sex differences in chiasma frequency from 54 species (4 hermaphroditic flatworms, 18 dioecious insects and vertebrates and 32...
متن کاملInitiation of genetic recombination and recombination-dependent replication.
Recombination initiates at double-stranded DNA breaks and at single-stranded DNA gaps. These DNA strand discontinuities can arise from DNA-damaging agents and from normal DNA replication when the DNA polymerase encounters an imperfection in the DNA template or another protein. The machinery of homologous recombination acts at these breaks and gaps to promote the events that result in gene recom...
متن کاملGenetic recombination: Sex-change operations in yeast
The 'directionality' of mating-type switching in building yeast is determined by mechanisms that regulate genetic recombination along the whole left arm of chromosome III. In MATa cells, a cis-acting 'recombinational enhancer' activates this entire region, while in MATalpha cells the enhancer is turned off by the alpha2 repressor.
متن کاملThe two-locus model with sex differences in recombination.
The criteria for stability of the equilibrium with D=0 are obtained for the two locus model with multiplicative or symmetric fitnesses when the recombination values in males and females are different. It is shown that if r is defined to be equal to the average of the recombination values in males and females, then the criteria are exactly the same as in the standard two locus model.-The equilib...
متن کاملComplementation, genetic conflict, and the evolution of sex and recombination.
The existence of sexual reproduction is difficult to explain because the 2-fold cost of meiosis requires a compensatory 2-fold advantage that is difficult to prove. Here, I show that asexual reproduction has a short-term disadvantage due to the loss of complementation of recessive deleterious mutations, which can overcome the 2-fold cost of meiosis in one or few generations. This complementatio...
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ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-018-0492-5